Retinoblastoma 1 antibody (pThr821)

Catalog No. ABIN1449258

This anti-Retinoblastoma 1 antibody is a Mouse Monoclonal antibody detecting Retinoblastoma 1 in WB. Suitable for Human.

Quick Overview for Retinoblastoma 1 antibody (pThr821) (ABIN1449258)

Target: Retinoblastoma 1 (RB1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 24A7

Product Details anti-Retinoblastoma 1 Antibody

Binding Specificity: pThr821

Specificity: This antibody specifically recognizes human Rb with phosphorylated at Thr821.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Alternative Name: Retinoblastoma-Associated Protein / RB1

Background: Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G 1 phase and halting inappropriate cell proliferation (Ref1 . At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU.1, ATF2, UBF, Elf-1 and c-Abl (Ref 2-4 . Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhibit the transcription and the cell cycle progression is inactivated by phosphorylation, which is catalyzed by the cyclin-d ependent protein kinases.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

Gene ID: 5925

NCBI Accession: NP_000312

UniProt: P06400

Pathways: Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy